Inhibitors | Comment | Organism | Structure |
---|---|---|---|
10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine | - |
Rattus norvegicus | |
galanthamine | - |
Rattus norvegicus | |
additional information | design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
butyrylthiocholine iodide + H2O | detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB | Rattus norvegicus | butyrate + thiocholine iodide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BChE | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0012 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine | |
0.0033 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine | |
0.0039 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine | |
0.0043 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine | |
0.0055 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine | |
0.0056 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine | |
0.0058 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine | |
0.0059 | - |
pH 7.4, 37°C | Rattus norvegicus | galanthamine | |
0.0071 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine | |
0.0094 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine | |
0.021 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine | |
0.024 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine | |
0.028 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine | |
0.029 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine | |
0.033 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine | |
0.034 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine | |
0.041 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine | |
0.053 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine | |
0.064 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine | |
0.093 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine |