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Literature summary for 3.1.1.8 extracted from

  • Decker, M.; Kraus, B.; Heilmann, J.
    Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties (2008), Bioorg. Med. Chem., 16, 4252-4261.
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
5-(1,2-dithiolan-3-yl)-N-[8-(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-ylideneamino)-octyl]pentanamide
-
 Mus musculus
5-ethoxy-3,4-dihydro-2H-pyrrole
-
 Mus musculus
6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Mus musculus
galanthamine
-
 Mus musculus
additional information design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties exhibiting competitive and reversible inhibition, overview Mus musculus
N-(3-([6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]amino)propyl)-5-(1,2-dithiolan-3-yl)pentanamide
-
 Mus musculus
N-(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-ylidene)octane-1,8-diamine
-
 Mus musculus
N-(8-([6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]amino)octyl)-5-(1,2-dithiolan-3-yl)-pentanamide
-
 Mus musculus
N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]-1-butanamine
-
 Mus musculus
N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]hexane-1,6-diamine
-
 Mus musculus
N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]octane-1,8-diamine
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
microglia
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
BChE
-
 Mus musculus
butyrylcholinesterase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0023
-
-
 Mus musculus N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]-1-butanamine