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Literature summary for 3.1.1.8 extracted from

  • Schallreuter, K.U.; Gibbons, N.C.; Elwary, S.M.; Parkin, S.M.; Wood, J.M.
    Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates (2007), Biochem. Biophys. Res. Commun., 355, 1069-1074.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates 9fold at 0.5 mM with substrate O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate via a specific EF-hand calcium binding site, molecular modelling of Ca2+ binding to EF-hands, disruption by H2O2-mediated oxidation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
butyrylthiocholine + H2O Homo sapiens
-
thiocholine + butyrate
-
?
additional information Homo sapiens calcium-activated butyrylcholinesterase as a major protective mechanism against suicide inhibition of acetylcholinesterase by organophosphates in this non-neuronal tissue ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyrylthiocholine + H2O
-
Homo sapiens thiocholine + butyrate
-
?
additional information calcium-activated butyrylcholinesterase as a major protective mechanism against suicide inhibition of acetylcholinesterase by organophosphates in this non-neuronal tissue Homo sapiens ?
-
?
O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
BuChE
-
Homo sapiens
calcium-activated butyrylcholinesterase
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens