Literature summary for 3.1.1.8 extracted from

Kovarik, Z.; Radic, Z.; Berman, H.A.; Simeon-Rudolf, V.; Reiner, E.; Taylor, P.
Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates (2004), Biochemistry, 43, 3222-3229.

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Inhibitors

Inhibitors	Comment	Organism	Structure
RP-3,3-dimethylbutyl-methylphosphonyl thiocholine	phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide	Mus musculus
RP-cycloheptyl-methylphosphonyl thiocholine	phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide	Mus musculus
RP-isopropyl methylphosphonyl thiocholine	phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide	Mus musculus
SP-3,3-dimethylbutyl-methylphosphonyl thiocholine	phosphonylates the enzyme, enzyme can be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide	Mus musculus
SP-cycloheptyl-methylphosphonyl thiocholine	phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide	Mus musculus
SP-isopropyl methylphosphonyl thiocholine	phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
butyrylthiocholine + H2O	-	Mus musculus	thiocholine + butyrate	-	?

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Release 2023.1 (January 2023)