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Literature summary for 3.1.1.73 extracted from

  • Vafiadi, C.; Topakas, E.; Wong, K.K.Y.; Suckling, I.D.; Christakopoulos, P.
    Mapping the hydrolytic and synthetic selectivity of a type C feruloyl esterase (StFaeC) from Sporotrichum thermophile using alkyl ferulates (2005), Tetrahedron, 16, 373-379.
No PubMed abstract available
Search for more literature for 3.1.1.73

Application

Application Comment Organism
medicine potential use for providing ferulic acid as precursor for the synthesis of cinnamic acid and its derivatives as anti-cancer drugs and for antimicrobial, antiviral and anti-inflammatory agents Thermothelomyces heterothallicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 iso-propyl ferulate hydrolysis Thermothelomyces heterothallicus
0.16
-
 2-butyl ferulate hydrolysis Thermothelomyces heterothallicus
0.19
-
 iso-butyl ferulate hydrolysis Thermothelomyces heterothallicus
0.51
-
 ethyl ferulate hydrolysis Thermothelomyces heterothallicus
0.51
-
 n-propyl ferulate hydrolysis Thermothelomyces heterothallicus
0.73
-
 n-butyl ferulate hydrolysis Thermothelomyces heterothallicus
1.64
-
 methyl ferulate hydrolysis Thermothelomyces heterothallicus
3 3.2 L-arabinose transesterification in a n-hexane/t-butanol/water solvent system, 35°C Thermothelomyces heterothallicus
68.9
-
 methyl ferulate transesterification in a n-hexane/t-butanol/water solvent system, 35°C Thermothelomyces heterothallicus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Thermothelomyces heterothallicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
feruloyl polysaccharide + H2O Thermothelomyces heterothallicus involved in the degradation of plant cell wall material, breaks ferulic acid cross-links between cell wall components ferulic acid + diferulic acid + ?
-
 ?

Organic Solvent Stability

Organic Solvent Comment Organism
n-hexane n-hexane/t-butanol/water, suitable solvent for transesterification Thermothelomyces heterothallicus
t-butanol n-hexane/t-butanol/water, suitable solvent for transesterification Thermothelomyces heterothallicus

Organism

Organism UniProt Comment Textmining
Thermothelomyces heterothallicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-butyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + 2-butanol
-
 ?
ethyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + ethanol
-
 ?
feruloyl polysaccharide + H2O involved in the degradation of plant cell wall material, breaks ferulic acid cross-links between cell wall components Thermothelomyces heterothallicus ferulic acid + diferulic acid + ?
-
 ?
iso-butyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + iso-butanol
-
 ?
iso-propyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + iso-propanol
-
 ?
methyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + methanol
-
 ?
methyl ferulate + L-arabinose 40% transesterification after 160 h Thermothelomyces heterothallicus L-arabinosyl ferulate + methanol
-
 ?
additional information the other substrates tested for hydrolysis show transesterification at rates between 2.7 and 6.3% Thermothelomyces heterothallicus ?
-
 ?
n-butyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + n-butanol
-
 ?
n-propyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + n-propanol
-
 ?

Synonyms

Synonyms Comment Organism
StFaeC
-
 Thermothelomyces heterothallicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
 transesterification Thermothelomyces heterothallicus
55
-
 hydrolytic activity Thermothelomyces heterothallicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
 unstable above 45°C when incubated at pH 6.0 for 6 h Thermothelomyces heterothallicus