Literature summary for 3.1.1.53 extracted from

Fitz, W.; Rosenthal, P.B.; Wong, C.H.
Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus (1996), Bioorg. Med. Chem., 4, 1349-1353.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
the inhibitor 2-alpha-thiomethylmercuryl 9-acetamido-9-deoxy sialoside is used to prepare heavy atom derivatives of the crystals	influenza C virus

Inhibitors

Inhibitors	Comment	Organism	Structure
2-alpha-thiomethylmercuryl 9-acetamido-9-deoxy sialoside	competitive inhibition, Ki: 4.2 mM; the inhibitor is used to prepare heavy atom derivatives of the crystals	influenza C virus

Organism

Organism	UniProt	Comment	Textmining
influenza C virus	-	-	-
influenza C virus Johannesburg/1/66	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-9-O-acetylneuraminate + H2O	-	influenza C virus	N-acetylneuraminate + acetate	-	?
N-acetyl-9-O-acetylneuraminate + H2O	-	influenza C virus Johannesburg/1/66	N-acetylneuraminate + acetate	-	?

Synonyms

Synonyms	Comment	Organism
9-O-acetylsialic acid esterase	-	influenza C virus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
4.2	-	2-alpha-thiomethylmercuryl 9-acetamido-9-deoxy sialoside	-	influenza C virus

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Release 2023.1 (January 2023)