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Literature summary for 3.1.1.53 extracted from
- Attachment of mouse hepatitis virus to O-acetylated sialic acid is mediated by hemagglutinin-esterase and not by the spike protein (2010), J. Virol., 84, 8970-8974.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of recombinant MHV-A59 derivatives in which the autologous genes for hemagglutinin-esterase and sialidase are replaced by those of MHV-S or MHV-DVIM by targeted RNA recombination. The mutants do not express functional hemagglutinin-esterase, in MHV-A59, the hemagglutinin-esterase gene is interrupted by a nonsense mutation at codon 15 and that consequently MHV-A59 and derivates rMHV-A59-SDVIM and rMHV-A59-SS do not express the hemagglutinin-esterase protein | Murine hepatitis virus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Murine hepatitis virus | MHV Sia receptor-binding specificity corresponds to the sialate-O-acetylesterase substrate preference of hemagglutinin-esterase , and hemagglutinin-esterase is sufficient to mediate virion binding to natural sialoglycoconjugates | ? | - |
? |  |
| additional information | Murine coronavirus | MHV Sia receptor-binding specificity corresponds to the sialate-O-acetylesterase substrate preference of hemagglutinin-esterase , and hemagglutinin-esterase is sufficient to mediate virion binding to natural sialoglycoconjugates | ? | - |
? | |
| additional information | Murine hepatitis virus strain S | MHV Sia receptor-binding specificity corresponds to the sialate-O-acetylesterase substrate preference of hemagglutinin-esterase, and hemagglutinin-esterase is sufficient to mediate virion binding to natural sialoglycoconjugates | ? | - |
? | |
| additional information | Murine coronavirus DVIM | MHV Sia receptor-binding specificity corresponds to the sialate-O-acetylesterase substrate preference of hemagglutinin-esterase , and hemagglutinin-esterase is sufficient to mediate virion binding to natural sialoglycoconjugates | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Betacoronavirus 1 | - |
- |
- |
| Murine coronavirus | - |
MHV-DVIM, a Murine coronavirus, MuCoV, or Mouse hepatitis virus, MHV, species | - |
| Murine coronavirus DVIM | - |
MHV-DVIM, a Murine coronavirus, MuCoV, or Mouse hepatitis virus, MHV, species | - |
| Murine hepatitis virus | - |
MHV-A59,a Murine coronavirus, MuCoV, or Mouse hepatitis virus, MHV, species | - |
| Murine hepatitis virus strain S | - |
MHV-S, a Murine coronavirus, MuCoV, or Mouse hepatitis virus, MHV, species | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl acetate + H2O | - |
Murine hepatitis virus | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Murine coronavirus | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Murine hepatitis virus strain S | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Betacoronavirus 1 | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Murine coronavirus DVIM | 4-nitrophenol + acetate | - |
? | |
| additional information | MHV Sia receptor-binding specificity corresponds to the sialate-O-acetylesterase substrate preference of hemagglutinin-esterase , and hemagglutinin-esterase is sufficient to mediate virion binding to natural sialoglycoconjugates | Murine hepatitis virus | ? | - |
? | |
| additional information | MHV Sia receptor-binding specificity corresponds to the sialate-O-acetylesterase substrate preference of hemagglutinin-esterase , and hemagglutinin-esterase is sufficient to mediate virion binding to natural sialoglycoconjugates | Murine coronavirus | ? | - |
? | |
| additional information | MHV Sia receptor-binding specificity corresponds to the sialate-O-acetylesterase substrate preference of hemagglutinin-esterase, and hemagglutinin-esterase is sufficient to mediate virion binding to natural sialoglycoconjugates | Murine hepatitis virus strain S | ? | - |
? | |
| additional information | MHV Sia receptor-binding specificity corresponds to the sialate-O-acetylesterase substrate preference of hemagglutinin-esterase , and hemagglutinin-esterase is sufficient to mediate virion binding to natural sialoglycoconjugates | Murine coronavirus DVIM | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hemagglutinin-esterase | - |
Murine hepatitis virus |
| hemagglutinin-esterase | - |
Murine coronavirus |
| hemagglutinin-esterase | - |
Murine hepatitis virus strain S |
| hemagglutinin-esterase | - |
Betacoronavirus 1 |
| sialate-O-acetylesterase | - |
Murine hepatitis virus |
| sialate-O-acetylesterase | - |
Murine coronavirus |
| sialate-O-acetylesterase | - |
Murine hepatitis virus strain S |
| sialate-O-acetylesterase | - |
Betacoronavirus 1 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | in apparent contrast to human and ungulate host range variants of Betacoronavirus-1, murine coronaviruses actually bind to O-Ac-sialic acids via hemagglutinin-esterase exclusively. Apparently, expansion of group A betacoronaviruses into new hosts and niches is accompanied by changes in hemagglutinin-esterase ligand and substrate preference and in the roles of hemagglutinin-esterase and sialidase in Sia receptor usage | Murine hepatitis virus |
| evolution | in apparent contrast to human and ungulate host range variants of Betacoronavirus-1, murine coronaviruses actually bind to O-Ac-sialic acids via hemagglutinin-esterase exclusively. Apparently, expansion of group A betacoronaviruses into new hosts and niches is accompanied by changes in hemagglutinin-esterase ligand and substrate preference and in the roles of hemagglutinin-esterase and sialidase in Sia receptor usage | Murine coronavirus |
| evolution | in apparent contrast to human and ungulate host range variants of Betacoronavirus-1, murine coronaviruses actually bind to O-Ac-sialic acids via hemagglutinin-esterase exclusively. Apparently, expansion of group A betacoronaviruses into new hosts and niches is accompanied by changes in hemagglutinin-esterase ligand and substrate preference and in the roles of hemagglutinin-esterase and sialidase in Sia receptor usage | Murine hepatitis virus strain S |
| evolution | in apparent contrast to human and ungulate host range variants of Betacoronavirus-1, murine coronaviruses actually bind to O-Ac-sialic acids via hemagglutinin-esterase exclusively. Apparently, expansion of group A betacoronaviruses into new hosts and niches is accompanied by changes in hemagglutinin-esterase ligand and substrate preference and in the roles of hemagglutinin-esterase and sialidase in Sia receptor usage | Betacoronavirus 1 |
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