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Literature summary for 3.1.1.53 extracted from

  • Cariappa, A.; Takematsu, H.; Liu, H.; Diaz, S.; Haider, K.; Boboila, C.; Kalloo, G.; Connole, M.; Shi, H.N.; Varki, N.; Varki, A.; Pillai, S.
    B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase (2009), J. Exp. Med., 206, 125-138.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.53

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface isoform Lse, secreted from post-Golgi vesicle, limited lysosomal localisation Mus musculus 9986
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enhanced B-cell receptor signalling through hyper-9-O-acetylation of alpha2-6-linked sialic acid on N-glycans and defective CD22 inhibitory signalling in absence of the enzyme ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Mus musculus
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 C57BL/6 wild-type or homozygous Siae deficient knockout mice, and B6.129S7-Rag1-deficient mice
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Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte catalytic regulation of B cell receptor (BCR) signalling and B-cell development, knockout mice: striking decrease in number of splenic marginal zone B-cells and marginal zone B-cell precursors, reduced number in follicular B-cells, loss of recirculating B-cells in bone marrow, lymphocyte-intrinsic defects Mus musculus
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splenocyte
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enhanced B-cell receptor signalling through hyper-9-O-acetylation of alpha2-6-linked sialic acid on N-glycans and defective CD22 inhibitory signalling in absence of the enzyme Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
9-O-acetyl sialic acid esterase Siae gene encodes two splice forms Mus musculus
Lse one splice variant Mus musculus
SIAE
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 Mus musculus
sialate-O-acetylesterase
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 Mus musculus
sialate: O-acetyl esterase
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 Mus musculus
sialic acid acetyl esterase
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 Mus musculus
sialic acid O-acetylesterase
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 Mus musculus

General Information

General Information Comment Organism
malfunction mice with a mutation in sialate: O-acetyl esterase (inframe deletion of exon 2, resulting in a protein lacking esterase activity) exhibit enhanced B cell receptor activation, defects in peripheral B cell development, and spontaneously develop antichromatin autoantibodies and glomerular immune complex deposits. The 9-O-acetylation state of sialic acid regulates the function of CD22, a Siglec that functions in vivo as an inhibitor of BCR signaling Mus musculus