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Literature summary for 3.1.1.47 extracted from

  • Tjoelker, L.W.; Wilder, C.; Eberhardt, C.; Stafforini, D.M.; Dietsch, G.; Schimpf, B.; Hooper, S.; Le Tong, H.; Cousens, L.S.; Zimmerman, G.A.; Yamada, Y.; McIntyre, T.M.; Prescott, S.M.; Gray, P.W.
    Anti-inflammatory properties of a platelet-activating factor acetylhydrolase [see comments (1995), Nature, 374, 549-553.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diisopropylfluorophosphate
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no stimulation by Ca2+ or Mg2+ Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45390
-
 sequence of cDNA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Homo sapiens the enzyme abolishes the inflammatory effects of the substrate on leukocytes and the vasculature ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O i.e. PAF Homo sapiens 1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
-
 ?
1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O
-
 Homo sapiens 1-hexadecyl-glycero-3-phosphocholine + glutarate
-
 ?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O the enzyme abolishes the inflammatory effects of the substrate on leukocytes and the vasculature Homo sapiens ?
-
 ?