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Literature summary for 3.1.1.47 extracted from
- Purification and characterization of bovine brain platelet-activating factor acetylhydrolase (1993), J. Biol. Chem., 268, 18748-18753.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diisopropylfluorophosphate | intracellular enzyme form Ib from brain | Bos taurus |  |
| p-bromophenacyl bromide | intracellular enzyme form Ib from brain | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | brain enzyme | Bos taurus | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29000 | - |
1 * 45000 + 1 * 30000 + 1 * 29000, intracellular enzyme form Ib from brain, SDS-PAGE | Bos taurus |
| 30000 | - |
1 * 45000 + 1 * 30000 + 1 * 29000, intracellular enzyme form Ib from brain, SDS-PAGE | Bos taurus |
| 45000 | - |
1 * 45000 + 1 * 30000 + 1 * 29000, intracellular enzyme form Ib from brain, SDS-PAGE | Bos taurus |
| 100000 | - |
intracellular enzyme form Ib from brain, gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | Bos taurus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| intracellular enzyme from brain, isoform Ib | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.45 | - |
intracellular enzyme form Ib from brain | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | i.e. PAF | Bos taurus | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | - |
Bos taurus | ? | - |
? | |
| additional information | no activity against phosphatidylcholine or phosphatidylethanolamine, but hydrolysis of a phosphatidylcholine with an oxidatively fragmented acyl chain at the sn-2 position | Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | 1 * 45000 + 1 * 30000 + 1 * 29000, intracellular enzyme form Ib from brain, SDS-PAGE | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
intracellular enzyme forms from brain | Bos taurus |
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