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Literature summary for 3.1.1.47 extracted from

  • Lu, J.; Pierce, M.; Franklin, A.; Jilling, T.; Stafforini, D.M.; Caplan, M.
    Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis (2010), Pediatr. Res., 68, 225-230.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information generation of enzyme-deficient PAF-AH-/- mice by targeted disruption of the mouse PAF-AH gene. Mortality rates are significantly lower in PAF-AH-/- pups compared to wild-type controls before 24 hours of life but surviving PAF-AH-/- animals are more susceptible to necrotizing enterocolitis, NEC, development compared to wild-type controls Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity ?
-
?
additional information Mus musculus C57/BL6J PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57/BL6J
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
Mus musculus
-
intestine
-
Mus musculus
-
plasma
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity Mus musculus ?
-
?
additional information PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity Mus musculus C57/BL6J ?
-
?

Synonyms

Synonyms Comment Organism
LpPLA2
-
Mus musculus
PAF-acetylhydrolase
-
Mus musculus
PAFAH
-
Mus musculus
PLA2G7
-
Mus musculus
platelet-activating factor acetylhydrolase
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

General Information

General Information Comment Organism
malfunction deletion of the plasma form of PAF-AH abolishes expression of serum and intestinal activities. Mortality rates are significantly lower in enzyme-deficient PAF-AH-/- pups compared to wild-type controls before 24 hours of life but surviving PAF-AH-/- animals are more susceptible to necrotizing enterocolitis, NEC, development compared to wild-type controls Mus musculus
physiological function the enzyme inactivates platelet-activating factor, PAF. Protective role for endogenous PAF-AH in the development of necrotizing enterocolitis, NEC, and endogenous PAF-AH deficiency may place them at increased risk for disease Mus musculus