Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of enzyme-deficient PAF-AH-/- mice by targeted disruption of the mouse PAF-AH gene. Mortality rates are significantly lower in PAF-AH-/- pups compared to wild-type controls before 24 hours of life but surviving PAF-AH-/- animals are more susceptible to necrotizing enterocolitis, NEC, development compared to wild-type controls | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity | ? | - |
? | |
additional information | Mus musculus C57/BL6J | PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57/BL6J | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood serum | - |
Mus musculus | - |
intestine | - |
Mus musculus | - |
plasma | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity | Mus musculus | ? | - |
? | |
additional information | PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity | Mus musculus C57/BL6J | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LpPLA2 | - |
Mus musculus |
PAF-acetylhydrolase | - |
Mus musculus |
PAFAH | - |
Mus musculus |
PLA2G7 | - |
Mus musculus |
platelet-activating factor acetylhydrolase | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of the plasma form of PAF-AH abolishes expression of serum and intestinal activities. Mortality rates are significantly lower in enzyme-deficient PAF-AH-/- pups compared to wild-type controls before 24 hours of life but surviving PAF-AH-/- animals are more susceptible to necrotizing enterocolitis, NEC, development compared to wild-type controls | Mus musculus |
physiological function | the enzyme inactivates platelet-activating factor, PAF. Protective role for endogenous PAF-AH in the development of necrotizing enterocolitis, NEC, and endogenous PAF-AH deficiency may place them at increased risk for disease | Mus musculus |