Cloned (Comment) | Organism |
---|---|
expression of a fragment, corresponding to nucleotides 599-1123 of the human PAF-AH cDNA, quantitative realtime RT-PCR expression analysis in MM6 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | - |
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Mono-Mac-6 cell | MM6 cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAF-AH | - |
Homo sapiens |
platelet-activating factor acetylhydrolase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | no effect by lyso-PAF on PAF-AH expression | additional information |
Homo sapiens | lipopolysaccharide and PAF strongly upregulate PAF-AH expression, the stimulation is susceptible to partial inhibition by p38 MAPK inhibitor SB-2033580 and PAF receptor antagonists WEB 2170 and BN50739, inhibition of the ERK1/2 portion of the MAPK pathway with PD98059 consistently increases PAF-AH expression relative to administration of lipopolysaccharide alone, overview. PAF-induced up-regulation of PAF-AH levels is solely mediated via the PAF receptor and is p38 MAPK-independent, lipopolysaccharide induce expression of the PAF receptor by 6-8fold | up |