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Literature summary for 3.1.1.47 extracted from
- The emerging roles of PAF acetylhydrolase (2009), J. Lipid Res., 50, S255-S259.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | Mammalia | - |
1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | expression of PAFAH2 mRNA | Mammalia | - |
| brain | robust expression of PLA2G7 mRNA | Mammalia | - |
| kidney | expression of PAFAH2 mRNA | Mammalia | - |
| liver | expression of PAFAH2 mRNA | Mammalia | - |
| liver | the type II liver isoform is found in several soft tissues | Mammalia | - |
| macrophage | - |
Mammalia | - |
| placenta | robust expression of PLA2G7 mRNA | Mammalia | - |
| secretion | - |
Mammalia | - |
| testis | expression of PAFAH2 mRNA | Mammalia | - |
| white adipose tissue | robust expression of PLA2G7 mRNA | Mammalia | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | - |
Mammalia | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
| additional information | group VII plasma and type II enzymes also hydrolyze unmodified sn-2 fatty acyl residues up to 5 or 6 carbon atoms long, but this length restriction is greatly relaxed when the omega-end of the sn-2 residue contains oxidized functions | Mammalia | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca2+-independent phospholipase A2 | - |
Mammalia |
| group VII phospholipase A2 | - |
Mammalia |
| group VIII phospholipase A2 | - |
Mammalia |
| lipoprotein associated phospholipase A2 | - |
Mammalia |
| LpPLA2 | - |
Mammalia |
| PAF acetylhydrolase | - |
Mammalia |
| PAF-AH | - |
Mammalia |
| PAFAH2 | - |
Mammalia |
| PLA2G7 | - |
Mammalia |
| plasma PAF-AH | - |
Mammalia |
| platelet-activating factor acetylhydrolase | - |
Mammalia |
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Release 2023.1 (January 2023)
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