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Literature summary for 3.1.1.47 extracted from
- Novel isoforms of intracellular platelet activating factor acetylhydrolase (PAFAH1b2) in human testis; encoded by alternatively spliced mRNAs (2007), Prostaglandins Other Lipid Mediat., 85, 69-80.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 17800 | - |
2 * 17800, SpV-1 forms higher molecular weight complexes ranging from 65000 Da to 110000 Da in addition to the 35000 Da complex calculated from sequence | Homo sapiens |
| 22800 | - |
x * 22800, calculated from sequence | Homo sapiens |
| 35000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | P68402 | isoform 1 | - |
| Homo sapiens | P68402 | isoform 2 | - |
| Homo sapiens | P68402 | isoform 3 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Homo sapiens | - |
| leukocyte | - |
Homo sapiens | - |
| additional information | only trace amounts of SpV-2 in leukocytes, heart, and pancreas | Homo sapiens | - |
| additional information | SpV-1 is ubiquitously expressed | Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| testis | SpV-2 is predominantly expressed in testis | Homo sapiens | - |
| testis | SpV-3 is predominantly expressed in testis | Homo sapiens | - |
| testis | SpV-4 SpV-4 has its highest expression in testis | Homo sapiens | - |
| testis | SpV-5 is expressed only in testis | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an important role in various physiological and pathophysiological functions including development, reproduction, inflammation, hemostasis, and apoptosis | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 22800, calculated from sequence | Homo sapiens |
| dimer | 2 * 17800, SpV-1 forms higher molecular weight complexes ranging from 65000 Da to 110000 Da in addition to the 35000 Da complex calculated from sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 1 | - |
Homo sapiens |
| intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 2 | - |
Homo sapiens |
| intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 3 | - |
Homo sapiens |
| intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 4 | - |
Homo sapiens |
| intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 5 | - |
Homo sapiens |
| PAFAH1B2 | - |
Homo sapiens |
| SpV-1 | - |
Homo sapiens |
| SpV-2 | - |
Homo sapiens |
| SpV-3 | - |
Homo sapiens |
| SpV-4 | - |
Homo sapiens |
| SpV-5 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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