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Literature summary for 3.1.1.47 extracted from

  • Karasawa, K.; Shirakura, M.; Harada, A.; Satoh, N.; Yokoyama, K.; Setaka, M.; Inoue, K.
    Red blood cells highly express type I platelet-activating factor-acetylhydrolase (PAF-AH) which consists of the alpha1/alpha2 complex (2005), J. Biochem., 138, 509-517.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Sus scrofa
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
1 * 26000 + 1 * 28000, dimer consisting of alpha1 and alpha2 subunit, SDS-PAGE, native mass by gel filtration Sus scrofa
28000
-
1 * 26000 + 1 * 28000, dimer consisting of alpha1 and alpha2 subunit, SDS-PAGE, native mass by gel filtration Sus scrofa
28000
-
2 * 28000, dimer consisting of two alpha2 subunits, SDS-PAGE, native mass by gel filtration Sus scrofa
60000
-
gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Sus scrofa enzyme from red blood cells is not involved in the degradation of platelet-activating factor accumulated in blood 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
?
phospholipid + H2O Sus scrofa degradation of phospholipids produced by oxidative stress ?
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
blood red blood cells Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.176
-
purified enzyme, 37°C, pH 7.0 Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O enzyme from red blood cells is not involved in the degradation of platelet-activating factor accumulated in blood Sus scrofa 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
?
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
-
Sus scrofa 1-O-hexadecyl-sn-glycerol-3-phosphocholine + acetate
-
?
phospholipid + H2O degradation of phospholipids produced by oxidative stress Sus scrofa ?
-
?

Subunits

Subunits Comment Organism
dimer 1 * 26000 + 1 * 28000, dimer consisting of alpha1 and alpha2 subunit, SDS-PAGE, native mass by gel filtration Sus scrofa
dimer 2 * 28000, dimer consisting of two alpha2 subunits, SDS-PAGE, native mass by gel filtration Sus scrofa

Synonyms

Synonyms Comment Organism
PAF-AH
-
Sus scrofa
platelet-activating factor-acetylhydrolase
-
Sus scrofa