Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is associated with low-density lipoprotein LDL and high-density lipoprotein HDL particles | Homo sapiens |
Application | Comment | Organism |
---|---|---|
diagnostics | the ratio of the HDL-associated enzyme to total plasma enzyme activity is a useful marker for atherogenicity in subjects with primary hypercholesterolemia | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | i.e. platelet-activation factor | 1-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
additional information | Homo sapiens | individuals with primary heterozygous or homozygous familial hypercholesterolemia show enhanced plasma enzyme activity compared to normolipidemic controls, thereby the level of plasma LDL, to which the enzyme is associated, is increased as well as the enzyme activity per LDL particle, level and activity of HDL-associated enzyme is unaltered | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Homo sapiens | 1-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
additional information | lipoprotein-associated phospholipase A2 activity | Homo sapiens | ? | - |
? | |
additional information | individuals with primary heterozygous or homozygous familial hypercholesterolemia show enhanced plasma enzyme activity compared to normolipidemic controls, thereby the level of plasma LDL, to which the enzyme is associated, is increased as well as the enzyme activity per LDL particle, level and activity of HDL-associated enzyme is unaltered | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipoprotein-associated phospholipase A2 | - |
Homo sapiens |
PAF-AH | - |
Homo sapiens |
platelet-activating factor-acetylhydrolase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |