Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | at least 2 isozymes I and II | Homo sapiens | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29000 | - |
1 * 29000, alpha1-subunit, + 1 * 30000, alpha2-subunit, + 1 * 45000, beta-subunit, fetal brain enzyme, SDS-PAGE, 1 * 20000-25000, alpha1-subunit, + 1 * 30000, alpha2-subunit, + 1 * 45000, beta-subunit, kidney and uterus enzyme, SDS-PAGE | Homo sapiens |
30000 | - |
1 * 29000, alpha1-subunit, + 1 * 30000, alpha2-subunit, + 1 * 45000, beta-subunit, fetal brain enzyme, SDS-PAGE, 1 * 20000-25000, alpha1-subunit, + 1 * 30000, alpha2-subunit, + 1 * 45000, beta-subunit, kidney and uterus enzyme, SDS-PAGE | Homo sapiens |
45000 | - |
1 * 29000, alpha1-subunit, + 1 * 30000, alpha2-subunit, + 1 * 45000, beta-subunit, fetal brain enzyme, SDS-PAGE, 1 * 20000-25000, alpha1-subunit, + 1 * 30000, alpha2-subunit, + 1 * 45000, beta-subunit, kidney and uterus enzyme, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | i.e. platelet-activation factor | 1-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | fetal | Homo sapiens | - |
kidney | - |
Homo sapiens | - |
myoma cell | at least 2 isozymes I and II, increased amount of isozyme I beta-subunit | Homo sapiens | - |
myometrium | at least 2 isozymes I and II | Homo sapiens | - |
uterus | isozyme I activity is lower in pregnant uterus compared to the nonpregnant one | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000008 | - |
cytosolic fraction, nonpregnant uterus | Homo sapiens |
0.000073 | - |
cytosolic fraction, pregnant uterine myometrium | Homo sapiens |
0.000221 | - |
cytosolic fraction, myoma | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Homo sapiens | 1-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
2-hexadecyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Homo sapiens | 1-hexadecyl-sn-glycero-3-phosphocholine + acetate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | isozyme I is a trimer of 2 alpha-subunits and one beta-subunit, isozyme II is a monomer | Homo sapiens |
trimer | 1 * 29000, alpha1-subunit, + 1 * 30000, alpha2-subunit, + 1 * 45000, beta-subunit, fetal brain enzyme, SDS-PAGE, 1 * 20000-25000, alpha1-subunit, + 1 * 30000, alpha2-subunit, + 1 * 45000, beta-subunit, kidney and uterus enzyme, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PAF acetylhydrolase | - |
Homo sapiens |
PAF-AH | - |
Homo sapiens |
platelet-activating factor acetylhydrolase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |