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Literature summary for 3.1.1.47 extracted from

  • Eisaf, M.; Tselepis, A.D.
    Effect of hypolipidemic drugs on lipoprotein-associated platelet activating factor acetylhydrolase. Implication for atherosclerosis (2003), Biochem. Pharmacol., 66, 2069-2073.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dyslipidemia induces an increase in total plasma enzyme activity and alters the enzyme distribution between proatherogenic apoB- and antiatherogenic apo L-containing lipoproteins by increasing the enzyme activity associated with apoB-containing lipoproteins, atorvastin and fenofibrate can restore the normal level by reduction of LDL amount Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
atorvastatin reduces LDL-associated enzyme activity by reduction of LDL amount, does not reduce enzyme secretion by macrophages Homo sapiens
fenofibrate decreases total plasma and LDL_associated enzyme activity but does not influence HDL-associated enzyme activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Homo sapiens the enzyme is essential for metabolism of platelet-activation factor and phospholipids, i.e. bioactive lipids that are involved in the pathophysiology of arherosclerosis 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
?
additional information Homo sapiens the enzyme is associated mainly with LDL containing apolipoprotein B, a small portion is also associated with HDL particles which play a predominantly antiatherogenic role ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage secretion Homo sapiens
-
plasma plasma isozyme Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O the enzyme is essential for metabolism of platelet-activation factor and phospholipids, i.e. bioactive lipids that are involved in the pathophysiology of arherosclerosis Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
?
additional information the enzyme is associated mainly with LDL containing apolipoprotein B, a small portion is also associated with HDL particles which play a predominantly antiatherogenic role Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
lipoprotein-associated platelet-activating factor acetylhydrolase
-
Homo sapiens
PAF-AH
-
Homo sapiens
platelet-activating factor acetylhydrolase
-
Homo sapiens