Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dyslipidemia | induces an increase in total plasma enzyme activity and alters the enzyme distribution between proatherogenic apoB- and antiatherogenic apo L-containing lipoproteins by increasing the enzyme activity associated with apoB-containing lipoproteins, atorvastin and fenofibrate can restore the normal level by reduction of LDL amount | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
atorvastatin | reduces LDL-associated enzyme activity by reduction of LDL amount, does not reduce enzyme secretion by macrophages | Homo sapiens | |
fenofibrate | decreases total plasma and LDL_associated enzyme activity but does not influence HDL-associated enzyme activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | the enzyme is essential for metabolism of platelet-activation factor and phospholipids, i.e. bioactive lipids that are involved in the pathophysiology of arherosclerosis | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
additional information | Homo sapiens | the enzyme is associated mainly with LDL containing apolipoprotein B, a small portion is also associated with HDL particles which play a predominantly antiatherogenic role | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | secretion | Homo sapiens | - |
plasma | plasma isozyme | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Homo sapiens | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | the enzyme is essential for metabolism of platelet-activation factor and phospholipids, i.e. bioactive lipids that are involved in the pathophysiology of arherosclerosis | Homo sapiens | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
additional information | the enzyme is associated mainly with LDL containing apolipoprotein B, a small portion is also associated with HDL particles which play a predominantly antiatherogenic role | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipoprotein-associated platelet-activating factor acetylhydrolase | - |
Homo sapiens |
PAF-AH | - |
Homo sapiens |
platelet-activating factor acetylhydrolase | - |
Homo sapiens |