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Literature summary for 3.1.1.41 extracted from
- Enzymatic hydrolysis of cephalosporin C by an extracellular acetylhydrolase of Cephalosporium acremonium (1976), Antimicrob. Agents Chemother., 9, 824-830.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DFP | - |
Acremonium chrysogenum |  |
| F- | weak | Acremonium chrysogenum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 20 | - |
cephalosporin C | - |
Acremonium chrysogenum | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Acremonium chrysogenum | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
sucrose density gradient centrifugation | Acremonium chrysogenum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Acremonium chrysogenum | addition of glucose, maltose, and sucrose to the culture broth suppresses the enzyme production | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acremonium chrysogenum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Acremonium chrysogenum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| culture medium | - |
Acremonium chrysogenum | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 5 | - |
- |
Acremonium chrysogenum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cephalosporin C + H2O | - |
Acremonium chrysogenum | deacetylcephalosporin C + acetate | - |
? | |
| additional information | addition of glucose, maltose, and sucrose to the culture broth suppresses the enzyme production | Acremonium chrysogenum | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CAH | - |
Acremonium chrysogenum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
- |
Acremonium chrysogenum |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | 55 | 20°C: about 30% of maximal activity, 55°C: about 10% of maximal activity | Acremonium chrysogenum |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
irreversible inactivation above | Acremonium chrysogenum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
hydrolysis of cephalosporin C | Acremonium chrysogenum |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.3 | pH 6.5: about 25% of maximal activity, pH 8.3: about 70% of maximal activity | Acremonium chrysogenum |
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