Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
15000 | - |
x * 15000, SDS-PAGE | Bothrops leucurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bothrops leucurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
CM-Sepharose column chromatography and phenyl-Sepharose column chromatography | Bothrops leucurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Bothrops leucurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
69.3 | - |
enzyme from crude venom, pH and temperature not specified in the publication | Bothrops leucurus |
159.9 | - |
purified enzyme, pH and temperature not specified in the publication | Bothrops leucurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme has hemolytic activity | Bothrops leucurus | ? | - |
? | |
phosphatidylcholine + H2O | - |
Bothrops leucurus | 1-acylglycerophosphocholine + fatty acid | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 15000, SDS-PAGE | Bothrops leucurus |
Synonyms | Comment | Organism |
---|---|---|
acidic phospholipase A2 | - |
Bothrops leucurus |
PLA2 | - |
Bothrops leucurus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Bothrops leucurus | isoelectric focusing | - |
5.4 |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme does not show myotoxic activity, but induces edema and actively participates in the pathogenesis of snake bite. The enzyme is able to induce increments in interleukin-12p40, TNF-alpha, interleukin-1beta and interleukin-6 levels and no variation of interleukin-8 and interleukin-10 in human peripheral blood mononuclear cells stimulated in vitro, suggesting that the enzyme induces proinflammatory cytokine production by human mononuclear cells | Bothrops leucurus |