Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyproheptadine | at a dose of 5 mg inhibits 82% promutoxin elicited microvascular leakage | Protobothrops mucrosquamatus | |
ginkgolide B | ginkgolide B at a dose of 5 mg inhibits 31% microvascular leakage induced by promutoxin when they are coinjected | Protobothrops mucrosquamatus | |
heparin | at a dose of 5 mg inhibits 49% promutoxin elicited microvascular leakage. At 10 and 100 microg/ml diminishes promutoxin-induced histamine release from lung mast cells by 56% and 53%, has little effect on promutoxin-induced histamine release from colon mast cells. At a concentration of 100 microg/ml, heparin inhibits promutoxin-induced histamine release from tonsil mast cells | Protobothrops mucrosquamatus | |
additional information | promutoxin induced histamine release from colon, lung and tonsil mast cells is inhibited by up to 89%, 99% and 90%, respectively when cells are pretreated with metabolic inhibitors for 40 min. Quinacrine at the dose of 5 mg has little effect on promutoxin provoked microvascular leakage in rat skin | Protobothrops mucrosquamatus | |
pertussis toxin | inhibits dramatically promutoxin-induced histamine release from colon mast cells, but has less effect on promutoxin-induced histamine release from lung cells | Protobothrops mucrosquamatus | |
terfenadine | at a dose of 5 mg inhibits 67% promutoxin elicited microvascular leakage | Protobothrops mucrosquamatus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Protobothrops mucrosquamatus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
gel filtration, at least 98% pure | Protobothrops mucrosquamatus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Protobothrops mucrosquamatus | - |
Storage Stability | Organism |
---|---|
-20°C | Protobothrops mucrosquamatus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
egg yolk + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
phosphatidylcholine + H2O | - |
Protobothrops mucrosquamatus | 1-acylglycerophosphocholine + a carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Arg49 phospholipase A2 | - |
Protobothrops mucrosquamatus |
promutoxin | - |
Protobothrops mucrosquamatus |
R49 PLA2 | - |
Protobothrops mucrosquamatus |
General Information | Comment | Organism |
---|---|---|
physiological function | promutoxin can provoke microvascular leakage in the skin of rats and induce a dose-dependent release of histamine from colon, lung and tonsil from human mast cells in vitro | Protobothrops mucrosquamatus |