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Literature summary for 3.1.1.4 extracted from

  • Meliton, A.Y.; Munoz, N.M.; Meliton, L.N.; Binder, D.C.; Osan, C.M.; Zhu, X.; Dudek, S.M.; Leff, A.R.
    Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro (2010), J. Inflamm., 7, 14.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information IL-8/CXCL8-induces gIVaPLA2 phosphorylation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
arachidonyl trifluoromethylketone causes inhibition to baseline level of gIVaPLA2 activity caused by IL-8/CXCL8 Homo sapiens
additional information inhibition of gIVaPLA2 blocks the deformability and subsequent migration of polymophonuclear leukocytes caused by IL-8/CXCL8 Homo sapiens
pyrrophenone potent gIVaPLA2 inhibitor, attenuates gIVaPLA2 activity in concentration-dependent manner Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol is located mainly in cytoplasm of unstimulated polymorphonuclear leukocytes Homo sapiens 5829
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nuclear membrane time-related phosphorylation and translocation of cytosolic gIVaPLA2 to the nucleus for polymorphonuclear leukocytes stimulated with IL-8/CXCL8 in concentration sufficient to cause upstream phosphorylation of MAPKs (ERK-1/2 and p38) and Akt/PKB Homo sapiens 31965
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
polymorphonuclear leukocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-palmitoyl-2-arachidonyl-phosphatidylcholine + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
cytosolic gIVaPLA2
-
Homo sapiens
cytosolic group IVa phospholipase A2
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Homo sapiens

General Information

General Information Comment Organism
physiological function activation of gIVaPLA2 is an essential step in polymophonuclear leukocyte migration in vitro. Change in polymorphonuclear leukocyte cell shape and migration correspond to increased activity of cytosolic gIVaPLA2 and translocation of gIVaPLA2 to the nuclear membrane. F-actin polymerization, another essential step for cell migration, is not regulated by gIVaPLA2 Homo sapiens