Literature summary for 3.1.1.4 extracted from

Chen, K.C.; Kao, P.H.; Lin, S.R.; Chang, L.S.
Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation (2009), J. Cell. Biochem., 106, 93-102.

Search for more literature for 3.1.1.4

Inhibitors

Inhibitors	Comment	Organism	Structure
4-bromophenacyl bromide	enzymatic activity of bromophenacylated PLA2 is approximate 0.06% of that of PLA2	Naja atra

Organism

Organism	UniProt	Comment	Textmining
Naja atra	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
venom	-	Naja atra	-

Synonyms

Synonyms	Comment	Organism
phospholipase A2	-	Naja atra
PLA2	-	Naja atra

General Information

General Information	Comment	Organism
physiological function	PLA2 induces caspase-dependent death in human SK-N-SH cells. PLA2 treatment induces Fas and FasL protein expression, leads to activation of p38 MAPK, inactivation of ERK, reactive oxygen species generation and elevation in intracellular Ca2+ concentration. PLA2-induced cell death is, in part, elicited by upregulation of Fas and FasL, which is regulated by Ca2+- and reactive oxygen species-evoked p38 MAPK activation, and suggests that non-catalytic PLA2 plays a role for the signaling pathway	Naja atra

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Release 2023.1 (January 2023)