Crystallization (Comment) | Organism |
---|---|
purified native enzyme, hanging drop vapour diffusion method, 8°C, X-ray diffraction structure determination and analysis at 2.2 A resolution, molecular replacement method | Naja atra |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secereted enzyme in venom | Naja atra | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | does only slightly alter the effects of the enzyme on K+ currents, overview | Naja atra |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Naja atra | the enzyme in venom effectively inhibits A-type K+ currents in mice and cause alterations of channel gating characters, such as the shifts of steadystate activation and inactivation curves to hyperpolarization direction and changes of V1/2 and slope factor, the effects are independent of the enzymatic activity as phospholipase, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Naja atra | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from venom by cation and anion exchange chromatography | Naja atra |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Naja atra | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme in venom effectively inhibits A-type K+ currents in mice and cause alterations of channel gating characters, such as the shifts of steadystate activation and inactivation curves to hyperpolarization direction and changes of V1/2 and slope factor, the effects are independent of the enzymatic activity as phospholipase, overview | Naja atra | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
natratoxin | - |
Naja atra |
secreted phospholipase A2 | - |
Naja atra |
secreted phospholipaseA2 neurotoxin | - |
Naja atra |
sPLA2 | - |
Naja atra |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.9 | - |
assay at | Naja atra |