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Literature summary for 3.1.1.4 extracted from

  • Burke, J.E.; Hsu, Y.H.; Deems, R.A.; Li, S.; Woods, V.L.; Dennis, E.A.
    A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2 (2008), J. Biol. Chem., 283, 31227-31236.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
methyl-arachidonyl fluorophosphonate an irreversible inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane GIVA phospholipase A2 associates with natural membranes in response to an increase in intracellular Ca2+ along with increases in certain lipid mediators, overview Homo sapiens 16020
-
additional information the isolated C2 domain binds a phospholipid membrane in the presence of Ca2+ in vitro Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P47712
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information inhibitor plus phospholipid vesicles cause a decreases at the C2 domain as well as charged residues on the putative membrane binding surface of the catalytic domain revealing the binding sites of the enzyme to the lipid surface, hypothetical model of initial membrane binding before lid opening, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cPLA2
-
 Homo sapiens
GIVA phospholipase A2
-
 Homo sapiens
group IVA cytosolic phospholipase A2
-
 Homo sapiens
group IVA phospholipase A2
-
 Homo sapiens