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Literature summary for 3.1.1.4 extracted from

  • da Silva, S.L.; Calgarotto, A.K.; Maso, V.; Damico, D.C.; Baldasso, P.; Veber, C.L.; Villar, J.A.; Oliveira, A.R.; Comar, M.; Oliveira, K.M.; Marangoni, S.
    Molecular modeling and inhibition of phospholipase A2 by polyhydroxy phenolic compounds (2009), Eur. J. Med. Chem., 44, 312-321.
    View publication on PubMed
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
1,3,5-trihydroxybenzene potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview Crotalus adamanteus
1,3-dihydroxy benzene potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview Crotalus adamanteus
2,4,6-trihydroxy acetophenone potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview Crotalus adamanteus
2,4-dihydroxy acetophenone binding structure, overview Crotalus adamanteus
2,6-dihydroxy acetophenone binding structure, overview Crotalus adamanteus
additional information molecular modeling of the inhibition mechanism of polyhydroxylated phenols Crotalus adamanteus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Crotalus adamanteus
-
-

Organism

Organism UniProt Comment Textmining
Crotalus adamanteus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme by gel filtration and C18 reverse phase HPLC Crotalus adamanteus

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Crotalus adamanteus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol + H2O micellar substrate Crotalus adamanteus ?
-
 ?
additional information the enzyme causes endema when applicated to the right footpad of male Swiss mice Crotalus adamanteus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Crotalus adamanteus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Crotalus adamanteus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000872
-
 1,3-dihydroxy benzene pH 8.0, 37°C Crotalus adamanteus
0.00000874
-
 2,4,6-trihydroxy acetophenone pH 8.0, 37°C Crotalus adamanteus
0.00000877
-
 1,3,5-trihydroxybenzene pH 8.0, 37°C Crotalus adamanteus
0.00003
-
 2,6-dihydroxy acetophenone pH 8.0, 37°C Crotalus adamanteus
0.000032
-
 2,4-dihydroxy acetophenone pH 8.0, 37°C Crotalus adamanteus