Literature summary for 3.1.1.4 extracted from

Qin, S.; Pande, A.H.; Nemec, K.N.; Tatulian, S.A.
The N-terminal alpha-helix of pancreatic phospholipase A2 determines productive-mode orientation of the enzyme at the membrane surface (2004), J. Mol. Biol., 344, 71-89.

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Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme fragment lacking N-terminal 10 amino acids, binds to membranes with weaker affinity and at random orientation, while wild-type binds in a defined orientation. Mutant has about 100fold lower enzymatic activity and less conformational flexibility than wild-type	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	expression in Escherichia coli	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Homo sapiens	-

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Release 2023.1 (January 2023)