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Literature summary for 3.1.1.4 extracted from

  • Valentin, E.; Lambeau, G.
    What can venom phospholipases A2 tell us about the functional diversity of mammalian secreted phospholipases A2? (2000), Biochimie, 82, 815-831.
    View publication on PubMed
Search for more literature for 3.1.1.4

Cloned(Commentary)

Cloned (Comment) Organism
-
 Pandinus imperator
-
 Pseudonaja textilis

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent Mammalia
Ca2+ dependent Crotalus atrox
Ca2+ dependent Exaiptasia diaphana
Ca2+ dependent Pandinus imperator
Ca2+ dependent Pseudonaja textilis
Ca2+ dependent Apis mellifera

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
 44000 Da and 43000 Da Exaiptasia diaphana
44000
-
 44000 Da and 43000 Da Exaiptasia diaphana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mammalia role in the digestion of prey, neurotoxic, myotoxic, cardiotoxic and cytotoxic activities, can have convulsant, hypotensive and proinflammatory effects, can affect blood coagulation and platelet aggregation, some forms can induce cell proliferation, cell migration and antibacterial activity. Mechanism of action can involve: the intrinsic catalytic activity of vPLA2, i.e. its ability to release potent biologically active fatty acids and lysophospholipids from membrane lipids, the interfacial binding to the membrane lipid bilayer which, without any phospholipid hydrolysis, may affect cellular functions by perturbing cellular membranes, and the binding to specific proteins located at the cell surface ?
-
 ?

Organism

Organism UniProt Comment Textmining
Apis mellifera P00630 bee
-
Crotalus atrox
-
-
-
Exaiptasia diaphana
-
 sea anemone
-
Mammalia
-
-
-
Pandinus imperator
-
 scorpion
-
Pseudonaja textilis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification enzyme has an uncleaved propeptide sequence with is catalytically inactive Pseudonaja textilis

Purification (Commentary)

Purification (Comment) Organism
-
 Exaiptasia diaphana

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Mammalia
-
venom
-
 Crotalus atrox
-
venom
-
 Exaiptasia diaphana
-
venom
-
 Pandinus imperator
-
venom
-
 Pseudonaja textilis
-
venom
-
 Apis mellifera
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information role in the digestion of prey, neurotoxic, myotoxic, cardiotoxic and cytotoxic activities, can have convulsant, hypotensive and proinflammatory effects, can affect blood coagulation and platelet aggregation, some forms can induce cell proliferation, cell migration and antibacterial activity. Mechanism of action can involve: the intrinsic catalytic activity of vPLA2, i.e. its ability to release potent biologically active fatty acids and lysophospholipids from membrane lipids, the interfacial binding to the membrane lipid bilayer which, without any phospholipid hydrolysis, may affect cellular functions by perturbing cellular membranes, and the binding to specific proteins located at the cell surface Mammalia ?
-
 ?

Subunits

Subunits Comment Organism
dimer homodimer Crotalus atrox

Synonyms

Synonyms Comment Organism
imperatoxin
-
 Pandinus imperator
notexinII-1
-
 Mammalia
phospholipin
-
 Pandinus imperator
taipoxin
-
 Mammalia
textilotoxin
-
 Pseudonaja textilis