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Literature summary for 3.1.1.34 extracted from

  • Glisic, S.; Arrigo, P.; Alavantic, D.; Perovic, V.; Prljic, J.; Veljkovic, N.
    Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease (2008), Proteins Struct. Funct. Bioinform., 70, 855-862.
    View publication on PubMed
Search for more literature for 3.1.1.34

Application

Application Comment Organism
medicine LPL mutations represent a risk factor which contributes to the development of cardiovascular disease Homo sapiens

Protein Variants

Protein Variants Comment Organism
D9N the mutation is associated with partial changes in enzyme function, plasma high density lipoprotein-C, triglyceride levels, and differential susceptibility to cardiovascular disease Homo sapiens
N291S the mutation is associated with partial changes in enzyme function, plasma high density lipoprotein-C, triglyceride levels, and differential susceptibility to cardiovascular disease Homo sapiens
S447X the mutation results in truncation of the last two amino acids of the mature LPL and is the only mutation reported to increase enzymatic activity, the mutation is associated with differential susceptibility to cardiovascular disease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P06858
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chylomicron + H2O
-
 Homo sapiens ?
-
 ?
triacylglycerol + H2O catalyzes the hydrolysis of triglycerides in circulating chylomicrons and very-low density lipoproteins Homo sapiens diacylglycerol + a carboxylate
-
 ?
triolein + H2O
-
 Homo sapiens oleate + diolein
-
 ?
very low density protein + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
homodimer dissociation of the dimeric form to the monomeric form is associated with a conformational change of the molecule and irreversible loss of catalytic activity Homo sapiens

Synonyms

Synonyms Comment Organism
LPL
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
apolipoprotein CII important cofactor Homo sapiens