Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.34 extracted from

  • Shan, L.; Yu, X.C.; Liu, Z.; Hu, Y.; Sturgis, L.T.; Miranda, M.L.; Liu, Q.
    The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms (2009), J. Biol. Chem., 284, 1419-1424.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.34

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

General Stability

General Stability Organism
heparin has a limited role in stabilizing the bound LPL active dimers Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
angiopoietin-like protein 3 mainly exhibits reversible inhibition of the catalytic activity of LPL, heparin is able to overcome the inhibitory effect of angiopoietin-like protein 3 on LPL at a concentration as low as 0.8 units/ml Homo sapiens
angiopoietin-like protein 4 heparin is not able to overcome the inhibitory effect of angiopoietin-like protein 4 on LPL at concentrations up to 10 units/ml Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-O-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester + H2O
-
 Homo sapiens ?
-
 ?
triacylglycerol + H2O
-
 Homo sapiens diacylglycerol + a carboxylate
-
 ?

Subunits

Subunits Comment Organism
dimer active enzyme Homo sapiens

Synonyms

Synonyms Comment Organism
LPL
-
 Homo sapiens