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Literature summary for 3.1.1.32 extracted from

  • Uchiyama, S.I.; Miyazaki, Y.; Amakasu, Y.; Kuwata, H.; Nakatani, Y.; Atsumi, G.I.; Murakami, M.; Kudo, I.
    Characterization of heparin low-affinity phospholipase A1 present in brain and testicular tissue (1999), J. Biochem., 125, 1001-1010.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
gentamycin the inhibition by aminoglycosides appears to be due to substrate depletion caused by binding of aminoglycosides to the negatively charged phospholipid and can be overcome by raising the substrate concentration Rattus norvegicus
tobramycin the inhibition by aminoglycosides appears to be due to substrate depletion caused by binding of aminoglycosides to the negatively charged phospholipid and can be overcome by raising the substrate concentration Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ independent of Ca2+ at pHs below 7.4, striking pH dependence at alkaline pH Mus musculus
Ca2+ independent of Ca2+ at pHs below 7.4, striking pH dependence at alkaline pH Rattus norvegicus
Ca2+ independent of Ca2+ at pHs below 7.4, striking pH dependence at alkaline pH Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus
-
Rattus norvegicus
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-
brain
-
Bos taurus
-
testis
-
Mus musculus
-
testis
-
Rattus norvegicus
-
testis
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity Mus musculus ?
-
?
additional information the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity Rattus norvegicus ?
-
?
additional information the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity Bos taurus ?
-
?
phosphatidylethanolamine + H2O
-
Mus musculus ?
-
?
phosphatidylethanolamine + H2O
-
Rattus norvegicus ?
-
?
phosphatidylethanolamine + H2O
-
Bos taurus ?
-
?