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Literature summary for 3.1.1.32 extracted from
- Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family (2007), Biochimie, 89, 197-204.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence analysis | Rattus norvegicus |
| DNA and amino acid sequence analysis of isozymes, isozyme genetic structures, location of isozyme PS-PLA1 or PLA1A encoding gene on chromosome 3q13.2-q13.3, phylogenetic analysis of isozymes, overview | Homo sapiens |
| DNA and amino acid sequence analysis of isozymes, location of isozyme PS-PLA1 or PLA1A encoding gene on chromosome 16 | Mus musculus |
| phylogenetic tree, overview | Cavia porcellus |
| phylogenetic tree, overview | Drosophila melanogaster |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | gene lpd encoding isozyme mPA-PLA1beta, i.e. the lipid defect locus lipase LPDL, homozygous insertion mutation leads to high levels of triacylglycerols in the plasma and hepatic steatosis | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Drosophila melanogaster | - |
- |
| extracellular | - |
Bombyx mori | - |
- |
| extracellular | - |
Dolichovespula maculata | - |
- |
| extracellular | isozyme PLA1S | Cavia porcellus | - |
- |
| extracellular | isozyme PLA1S | Mus musculus | - |
- |
| extracellular | isozyme PLA1S | Homo sapiens | - |
- |
| extracellular | isozyme PLA1S | Rattus norvegicus | - |
- |
| membrane | associated, phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Cavia porcellus | 16020 | - |
| membrane | associated, phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Homo sapiens | 16020 | - |
| membrane | associated, phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Rattus norvegicus | 16020 | - |
| membrane | associated, phosphatidic acid-specific isozymes mPA-PLA1alpha or lipase H, and mPA-PLA1beta or lacrimal lipase | Mus musculus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | isozyme mPA-PLA1beta is identical to the lipid defect locus lipase LPDL, encoded by gene lpd, homozygous insertion mutation leads to high levels of triacylglycerols in the plasma and hepatic steatosis | ? | - |
? |  |
| additional information | Mus musculus | isozyme mPA-PLA1beta might plays a role in tumor progression | ? | - |
? | |
| phosphatidylcholine + H2O | Cavia porcellus | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | Drosophila melanogaster | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | Mus musculus | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | Homo sapiens | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | Rattus norvegicus | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | Bombyx mori | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | Dolichovespula maculata | - |
2-acylglycerophosphocholine + a carboxylate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bombyx mori | - |
- |
- |
| Cavia porcellus | - |
several isozymes | - |
| Dolichovespula maculata | - |
hornet | - |
| Drosophila melanogaster | - |
- |
- |
| Homo sapiens | - |
several isozymes | - |
| Mus musculus | - |
several isozymes | - |
| Rattus norvegicus | - |
several isozymes | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Cavia porcellus | |
| phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Drosophila melanogaster | |
| phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Mus musculus | |
| phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Homo sapiens | |
| phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Rattus norvegicus | |
| phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Bombyx mori | |
| phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate | structure-function relationship | Dolichovespula maculata |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | isozyme mPA-PLA1alpha | Mus musculus | - |
| blood platelet | isozyme PS-PLA1 or PLA1A | Rattus norvegicus | - |
| brain | isozyme mPA-PLA1alpha | Mus musculus | - |
| colon | isozyme mPA-PLA1alpha | Mus musculus | - |
| endothelium | isozyme endothelial lipase | Cavia porcellus | - |
| endothelium | isozyme endothelial lipase | Mus musculus | - |
| endothelium | isozyme endothelial lipase | Homo sapiens | - |
| endothelium | isozyme endothelial lipase | Rattus norvegicus | - |
| heart | isozyme mPA-PLA1alpha | Mus musculus | - |
| heart | isozyme PS-PLA1 or PLA1A | Rattus norvegicus | - |
| kidney | isozyme mPA-PLA1alpha | Mus musculus | - |
| liver | isozyme hepatic lipase | Cavia porcellus | - |
| liver | isozyme hepatic lipase | Mus musculus | - |
| liver | isozyme hepatic lipase | Homo sapiens | - |
| liver | isozyme hepatic lipase | Rattus norvegicus | - |
| lung | isozyme mPA-PLA1alpha | Mus musculus | - |
| lung | isozyme PS-PLA1 or PLA1A | Rattus norvegicus | - |
| mast cell | peritoneal, isozyme PS-PLA1 or PLA1A | Rattus norvegicus | - |
| ovary | isozyme mPA-PLA1alpha | Mus musculus | - |
| pancreas | pancreatic lipase-related protein 2 | Cavia porcellus | - |
| pancreas | pancreatic lipase-related protein 2 | Homo sapiens | - |
| pancreas | pancreatic lipase-related protein 2 | Rattus norvegicus | - |
| pancreas | pancreatic lipase-related protein 2, isozyme mPA-PLA1alpha | Mus musculus | - |
| pancreatic acinar cell | - |
Homo sapiens | - |
| pancreatic juice | - |
Homo sapiens | - |
| plasma | isozyme mPA-PLA1beta | Homo sapiens | - |
| prostate | isozyme mPA-PLA1alpha | Mus musculus | - |
| sperm | isozyme mPA-PLA1beta | Mus musculus | - |
| spleen | isozyme mPA-PLA1alpha | Mus musculus | - |
| testis | isozyme mPA-PLA1alpha and isozyme mPA-PLA1beta | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | isozyme mPA-PLA1beta is identical to the lipid defect locus lipase LPDL, encoded by gene lpd, homozygous insertion mutation leads to high levels of triacylglycerols in the plasma and hepatic steatosis | Homo sapiens | ? | - |
? | |
| additional information | isozyme mPA-PLA1beta might plays a role in tumor progression | Mus musculus | ? | - |
? | |
| additional information | several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity | Cavia porcellus | ? | - |
? | |
| additional information | several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity | Mus musculus | ? | - |
? | |
| additional information | several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity | Homo sapiens | ? | - |
? | |
| additional information | several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity | Rattus norvegicus | ? | - |
? | |
| phosphatidic acid + H2O | phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Cavia porcellus | ? | - |
? | |
| phosphatidic acid + H2O | phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Homo sapiens | ? | - |
? | |
| phosphatidic acid + H2O | phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Rattus norvegicus | ? | - |
? | |
| phosphatidic acid + H2O | phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta | Mus musculus | 2-acyllysophosphatidic acid + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | - |
Cavia porcellus | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | - |
Drosophila melanogaster | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | - |
Mus musculus | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | - |
Homo sapiens | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | - |
Rattus norvegicus | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | - |
Bombyx mori | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylcholine + H2O | - |
Dolichovespula maculata | 2-acylglycerophosphocholine + a carboxylate | - |
? | |
| phosphatidylserine + H2O | phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A | Cavia porcellus | ? | - |
? | |
| phosphatidylserine + H2O | phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A | Mus musculus | ? | - |
? | |
| phosphatidylserine + H2O | phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A | Homo sapiens | ? | - |
? | |
| phosphatidylserine + H2O | phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | amino acid sequence comparison | Dolichovespula maculata |
| More | isozyme tertiary structure analysis, amino acid sequence comparison | Homo sapiens |
| More | isozyme tertiary structure analysis, amino acid sequence comparison, overview | Cavia porcellus |
| More | isozyme tertiary structure analysis, overview | Drosophila melanogaster |
| More | isozyme tertiary structure analysis, overview | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| endothelial lipase | - |
Cavia porcellus |
| endothelial lipase | - |
Mus musculus |
| endothelial lipase | - |
Homo sapiens |
| endothelial lipase | - |
Rattus norvegicus |
| hepatic lipase | - |
Cavia porcellus |
| hepatic lipase | - |
Mus musculus |
| hepatic lipase | - |
Homo sapiens |
| hepatic lipase | - |
Rattus norvegicus |
| lacrimal lipase | - |
Mus musculus |
| lipase H | - |
Mus musculus |
| More | the enzyme belongs to the pancreatic lipase gene family | Drosophila melanogaster |
| More | the enzyme belongs to the pancreatic lipase gene family | Bombyx mori |
| More | the enzyme belongs to the pancreatic lipase gene family | Dolichovespula maculata |
| More | the isozymes belong to the pancreatic lipase gene family or to the phospholipase family | Cavia porcellus |
| More | the isozymes belong to the pancreatic lipase gene family or to the phospholipase family | Mus musculus |
| More | the isozymes belong to the pancreatic lipase gene family or to the phospholipase family | Homo sapiens |
| More | the isozymes belong to the pancreatic lipase gene family or to the phospholipase family | Rattus norvegicus |
| mPA-PLA1alpha | - |
Cavia porcellus |
| mPA-PLA1alpha | - |
Mus musculus |
| mPA-PLA1alpha | - |
Homo sapiens |
| mPA-PLA1alpha | - |
Rattus norvegicus |
| mPA-PLA1beta | - |
Cavia porcellus |
| mPA-PLA1beta | - |
Mus musculus |
| mPA-PLA1beta | - |
Homo sapiens |
| mPA-PLA1beta | - |
Rattus norvegicus |
| pancreatic lipase-related protein 2 | - |
Cavia porcellus |
| pancreatic lipase-related protein 2 | - |
Mus musculus |
| pancreatic lipase-related protein 2 | - |
Homo sapiens |
| pancreatic lipase-related protein 2 | - |
Rattus norvegicus |
| PLA1 | - |
Cavia porcellus |
| PLA1 | - |
Drosophila melanogaster |
| PLA1 | - |
Mus musculus |
| PLA1 | - |
Homo sapiens |
| PLA1 | - |
Rattus norvegicus |
| PLA1 | - |
Bombyx mori |
| PLA1 | - |
Dolichovespula maculata |
| PLA1S | - |
Cavia porcellus |
| PLA1S | - |
Mus musculus |
| PLA1S | - |
Homo sapiens |
| PLA1S | - |
Rattus norvegicus |
| PLRP2 | - |
Cavia porcellus |
| PLRP2 | - |
Mus musculus |
| PLRP2 | - |
Homo sapiens |
| PLRP2 | - |
Rattus norvegicus |
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