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Literature summary for 3.1.1.31 extracted from
- Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase. A novel bifunctional enzyme in malaria parasites (2001), Eur. J. Biochem., 268, 2013-2019.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
| expression in Escherichia coli | Plasmodium berghei |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phospho-D-glucono-1,5-lactone + H2O | Homo sapiens | second step in pentose phosphate pathway | 6-phospho-D-gluconate | - |
? |  |
| 6-phospho-D-glucono-1,5-lactone + H2O | Plasmodium berghei | second step in pentose phosphate pathway | 6-phospho-D-gluconate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Plasmodium berghei | - |
bifunctional enzyme having also ec 1.1.1.49, i.e. glucose 6-phosphate dehydrogenase, activity | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant 6PGL | Homo sapiens |
| recombinant Glc6PD-6PGL | Plasmodium berghei |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1 | - |
recombinant Glc6PD-6PGL | Plasmodium berghei |
| 54.2 | - |
recombinant 6PGL | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-phospho-D-glucono-1,5-lactone + H2O | - |
Homo sapiens | 6-phospho-D-gluconate | - |
? | |
| 6-phospho-D-glucono-1,5-lactone + H2O | - |
Plasmodium berghei | 6-phospho-D-gluconate | - |
? | |
| 6-phospho-D-glucono-1,5-lactone + H2O | second step in pentose phosphate pathway | Homo sapiens | 6-phospho-D-gluconate | - |
? | |
| 6-phospho-D-glucono-1,5-lactone + H2O | second step in pentose phosphate pathway | Plasmodium berghei | 6-phospho-D-gluconate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-phosphogluconolactonase | - |
Homo sapiens |
| 6PGL | - |
Homo sapiens |
| Glc6PD-6PGL | - |
Plasmodium berghei |
| glucose-6-phosphate dehydrognease-6-phosphogluconolactonase | - |
Plasmodium berghei |
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