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Literature summary for 3.1.1.3 extracted from

  • Miyoshi, H.; Perfield, J.W.; Obin, M.S.; Greenberg, A.S.
    Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes (2008), J. Cell. Biochem., 105, 1430-1436.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.3

Cloned(Commentary)

Cloned (Comment) Organism
expression of ATGL and HSL in Peri A-deficient and wild-type mouse embryonic fibroblasts Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information HSL-directed shRNAi does not significantly alter basal glycerol or fatty acid release when compared with control. ATGL-directed shRNAi significantly decreases both glycerol and fatty acid release in the absence of Peri A. Knockdown of ATGL dramatically increases triacyl glyceride storage compared with control both in the absence or presence of Peri A. In contrast, knockdown of HSL does not alter triacyl glyceride storage significantly regardless of Peri A expression Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm ATGL and HSL are located mainly in the cytoplasm Mus musculus 5737
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus HSL translocates from the cytoplasm to the lipid droplet surface and interacts with Peri A in stimulated lipolysis ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
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 Mus musculus
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adipose tissue
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information HSL translocates from the cytoplasm to the lipid droplet surface and interacts with Peri A in stimulated lipolysis Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
adipose triglyceride lipase
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 Mus musculus
ATGL
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 Mus musculus
hormone-sensitive lipase
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 Mus musculus
HSL
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 Mus musculus

General Information

General Information Comment Organism
physiological function ATGL participates in basal lipolysis in adipocytes, whereas the role of HSl is minor. In the basal state ATGL is a major regulator of triacylglyceride storage in adipocytes and its effects are independent of Peri A expression. HSL expression does not affect lipid droplet size regardless of Peri A expression Mus musculus