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Literature summary for 3.1.1.3 extracted from
- Exploring the active site cavity of human pancreatic lipase (2008), Biochem. Biophys. Res. Commun., 370, 394-398.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Pichia pastoris strain GS115 and Sf21 insect cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H151A | mutant shows changed pH-activity profile and reduced lipase activity compared to the wild type enzyme | Homo sapiens |
| K80E | mutant shows changed pH-activity profile and reduced lipase activity compared to the wild type enzyme | Homo sapiens |
| L264E | mutant shows changed pH-activity profile and reduced lipase activity compared to the wild type enzyme | Homo sapiens |
| Y114F | mutant shows changed pH-activity profile and reduced lipase activity compared to the wild type enzyme | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sodium taurodeoxycholate | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tributyrin + H2O | - |
Homo sapiens | dibutyrin + butyrate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipase | - |
Homo sapiens |
| triacylglycerol acylhydrolase | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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