Literature summary for 3.1.1.3 extracted from

MOrgan, B.; Dodds, D.R.; Zaks, A.; Andrews, D.R.; Klesse, R.
Enzymatic desymmetrization of prochiral 2-substituted-1,3-propanediols: A practical chemoenzymatic synthesis of a key precursor of SCH51048, a broad-spectrum orally active antifungal agent (1997), J. Org. Chem., 62, 7736-7743.

No PubMed abstract available

Search for more literature for 3.1.1.3

Application

Application	Comment	Organism
synthesis	production of (S)-acetic acid 4-(2,4-difluoro-phenyl)-2-hydroxymethyl-pent-4-enyl ester, which is used as an improved azole antifungal. It shows activity against systemic Candida and pulmonary Aspergillus infections	Moesziomyces antarcticus

Organism

Organism	UniProt	Comment	Textmining
Moesziomyces antarcticus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-[2-(2,4-difluoro-phenyl)-allyl]-propane-1,3-diol + vinyl acetate	-	Moesziomyces antarcticus	(S)-acetic acid 4-(2,4-difluoro-phenyl)-2-hydroxymethyl-pent-4-enyl ester + acetic acid 2-acetoxymethyl-4-(2,4-difluoro-phenyl)-pent-4-enyl-ester	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
-	-	-	Moesziomyces antarcticus

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Release 2023.1 (January 2023)