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Literature summary for 3.1.1.23 extracted from

  • Savinainen, J.R.; Kansanen, E.; Pantsar, T.; Navia-Paldanius, D.; Parkkari, T.; Lehtonen, M.; Laitinen, T.; Nevalainen, T.; Poso, A.; Levonen, A.L.; Laitinen, J.T.
    Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL) (2014), Mol. Pharmacol., 86, 522-535.
    View publication on PubMed
Search for more literature for 3.1.1.23

Inhibitors

Inhibitors Comment Organism Structure
[4-[bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone a highly potent selective inhibitor Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0097
-
 2-arachidonoylglycerol at pH 7.4 and 37°C Homo sapiens
0.0122
-
 2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol at pH 7.4 and 37°C Homo sapiens
0.02
-
 1-decanoyl-rac-glycerol at pH 7.4 and 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
 x * 33000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-arachidonoylglycerol + H2O Homo sapiens best substrate glycerol + arachidonic acid
-
 ?
2-arachidonoylglycerol + H2O Homo sapiens
-
 glycerol + arachidonic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q99685
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-arachidonoylglycerol + H2O best substrate Homo sapiens glycerol + arachidonic acid
-
 ?
1-decanoyl-rac-glycerol + H2O
-
 Homo sapiens glycerol + decanoic acid
-
 ?
2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol + H2O highest preference Homo sapiens ?
-
 ?
2-arachidonoylglycerol + H2O
-
 Homo sapiens glycerol + arachidonic acid
-
 ?
prostaglandin D2-glycerol + H2O
-
 Homo sapiens ?
-
 ?
prostaglandin E2-glycerol + H2O
-
 Homo sapiens ?
-
 ?
prostaglandin F2alpha-glycerol + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 33000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MAGL
-
 Homo sapiens
monoacylglycerol lipase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000002
-
 at pH 7.4 and 37°C Homo sapiens [4-[bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone