Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-arachidonoylglycerol + H2O | more than 80% of 2-arachidonoylglycerol (0.05 mM) is hydrolyzed after 90 min in the presence of 0.02 mg of MAGL(+/+) brain extracts at room temperature | Mus musculus | glycerol + arachidonic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAGL | - |
Mus musculus |
monoacylglycerol lipase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mice lacking MAGL exhibit dramatically reduced 2-arachidonoylglycerol hydrolase activity and highly elevated 2-arachidonoylglycerol levels in the nervous system leading to desensitization of brain CB1 receptors with a significant reduction of cannabimimetic effects of CB1 agonists. MAGL-deficient mice do not show alterations in neuropathic and inflammatory pain sensitivity | Mus musculus |
physiological function | monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system | Mus musculus |