Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 (DE3) cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0088 | - |
arachidonoyl-7-hydroxy-6-methoxy-4-methylcoumarin ester | recombinant enzyme, in TME buffer, at 37°C | Homo sapiens | |
0.0197 | - |
2-arachidonoylglycerol | recombinant enzyme, in TME buffer, at 37°C | Homo sapiens | |
0.0336 | - |
2-arachidonoylglycerol | native enzyme, in TME buffer, at 37°C | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-arachidonoylglycerol + H2O | Rattus norvegicus | - |
arachidonic acid + glycerol | - |
? | |
2-arachidonoylglycerol + H2O | Homo sapiens | MGL modulates endocannabinoid signaling in vivo by inactivating 2-arachidonoylglycerol (2-AG), the main endogenous agonist for central CB1 and peripheral CB2 cannabinoid receptors | arachidonic acid + glycerol | - |
? | |
arachidonoyl-7-hydroxy-6-methoxy-4-methylcoumarin ester + H2O | Homo sapiens | - |
arachidonic acid + 7-hydroxy-6-methoxy-4-methylcoumarin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q99685 | - |
- |
Rattus norvegicus | Q8R431 | - |
- |
Purification (Comment) | Organism |
---|---|
immobilized metal affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-arachidonoylglycerol + H2O | - |
Rattus norvegicus | arachidonic acid + glycerol | - |
? | |
2-arachidonoylglycerol + H2O | MGL modulates endocannabinoid signaling in vivo by inactivating 2-arachidonoylglycerol (2-AG), the main endogenous agonist for central CB1 and peripheral CB2 cannabinoid receptors | Homo sapiens | arachidonic acid + glycerol | - |
? | |
arachidonoyl-7-hydroxy-6-methoxy-4-methylcoumarin ester + H2O | - |
Homo sapiens | arachidonic acid + 7-hydroxy-6-methoxy-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MGL | - |
Rattus norvegicus |
MGL | - |
Homo sapiens |
monoacylglycerol lipase | - |
Rattus norvegicus |
monoacylglycerol lipase | - |
Homo sapiens |