Literature summary for 3.1.1.23 extracted from

Nomura, D.K.; Hudak, C.S.; Ward, A.M.; Burston, J.J.; Issa, R.S.; Fisher, K.J.; Abood, M.E.; Wiley, J.L.; Lichtman, A.H.; Casida, J.E.
Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels (2008), Bioorg. Med. Chem. Lett., 18, 5875-5878.

Search for more literature for 3.1.1.23

Inhibitors

Inhibitors	Comment	Organism	Structure
1-methylethyl dodecylphosphonofluoridoate	highly potent inhibitor	Mus musculus
2-(nonylsulfanyl)-4H-1,3,2-benzodioxaphosphinine 2-oxide	-	Mus musculus
4-cyanophenyl ethyl dodecylphosphonate	highly potent inhibitor	Mus musculus
4-nitrophenyl dodecyl(1-methylethyl)phosphinate	-	Mus musculus
diethyl 3,5,6-trichloropyridin-2-yl phosphate	-	Mus musculus
diethyl 4-nitrophenyl phosphate	-	Mus musculus
dodecane-1-sulfonyl fluoride	-	Mus musculus
ethyl 3,5,6-trichloropyridin-2-yl dodecylphosphonate	-	Mus musculus
methyl icosylphosphonofluoridoate	-	Mus musculus
octane-1-sulfonyl fluoride	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
liver	-	Mus musculus	-
lung	-	Mus musculus	-
spleen	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-arachidonoylglycerol + H2O	-	Mus musculus	arachidonic acid + glycerol	-	?

Synonyms

Synonyms	Comment	Organism
MAGL	-	Mus musculus
monoacylglycerol lipase	-	Mus musculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00000007	-	-	Mus musculus	4-cyanophenyl ethyl dodecylphosphonate
0.00000014	-	-	Mus musculus	ethyl 3,5,6-trichloropyridin-2-yl dodecylphosphonate
0.00000028	-	-	Mus musculus	4-nitrophenyl dodecyl(1-methylethyl)phosphinate
0.00000031	-	-	Mus musculus	2-(nonylsulfanyl)-4H-1,3,2-benzodioxaphosphinine 2-oxide
0.0000008	-	-	Mus musculus	1-methylethyl dodecylphosphonofluoridoate
0.000002	-	-	Mus musculus	methyl icosylphosphonofluoridoate
0.00001	-	-	Mus musculus	diethyl 3,5,6-trichloropyridin-2-yl phosphate
0.00014	-	-	Mus musculus	octane-1-sulfonyl fluoride
0.0002	-	-	Mus musculus	dodecane-1-sulfonyl fluoride
0.0023	-	-	Mus musculus	diethyl 4-nitrophenyl phosphate

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)