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Literature summary for 3.1.1.23 extracted from

  • Quistad, G.B.; Klintenberg, R.; Caboni, P.; Liang, S.N.; Casida, J.E.
    Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice (2006), Toxicol. Appl. Pharmacol., 211, 78-83.
    View publication on PubMed
Search for more literature for 3.1.1.23

Inhibitors

Inhibitors Comment Organism Structure
benzol IC50 is 0.012 mM Mus musculus
chlorpyrifos oxon IC50 is 34 nM Mus musculus
decyl benzodioxaphosphorin oxide IC50 is 0.80 nM Mus musculus
diazoxon IC50 is 0.014 mM Mus musculus
dichlorvos IC50 is 0.013 mM Mus musculus
diisopropyl fluorophosphate i.e. DFP, n-C8H17P(O)(OCH3)F, IC50 is 0.045 mM Mus musculus
dodecyl benzodioxaphosphorin oxide IC50 is 0.83 nM Mus musculus
dodecyl sulfonyl fluoride IC50 is 200 nM Mus musculus
ethyl octylphosphonofluoridate i.e. EOFP, n-C8H17P(O)(OC2H5)F, IC50 is 3.0 nM Mus musculus
heptyl benzodioxaphosphorin oxide IC50 is 45 nM Mus musculus
isopropyl dodecylfluorophosphate i.e. IDFP, n-C12H25P(O)(OCH3)F, IC50 is 0.76 nM Mus musculus
methyl arachidonyl fluorophosphonate i.e. MAFP, n-C20H33P(O)(OCH3)F Mus musculus
methyl octylphosphonofluoridate i.e. MOFP, n-C8H17P(O)(OCH3)F, IC50 is 3.0 nM Mus musculus
additional information analysis of structure-function relationships; analysis of structure-function relationships, organophosphorus-induced in vivo inhibition, overview Mus musculus
N-n-heptyl benzodioxaphosphorin oxide IC50 is 150 nM Mus musculus
O-n-octyl benzodioxaphosphorin oxide IC50 is 150 nM Mus musculus
octyl sulfonyl fluoride IC50 is 140 nM Mus musculus
paraoxon IC50 is 0.0023 mM Mus musculus
S-heptyl benzodioxaphosphorin oxide IC50 is 2.9 nM Mus musculus
S-nonyl benzodioxaphosphorin oxide IC50 is 0.31 nM Mus musculus
S-pentyl benzodioxaphosphorin oxide IC50 is 3.1 nM Mus musculus
stearyl benzodioxaphosphorin oxide IC50 is 51 nM Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male albino Swiss-Webster mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-arachidonoylglycerol + H2O
-
 Mus musculus arachidonic acid + glycerol
-
 ?
1-oleoylglycerol + H2O
-
 Mus musculus oleic acid + glycerol
-
 ?
2-arachidonoylglycerol + H2O
-
 Mus musculus arachidonic acid + glycerol
-
 ?
2-oleoylglycerol + H2O
-
 Mus musculus oleic acid + glycerol
-
 ?
3-oleoylglycerol + H2O
-
 Mus musculus oleic acid + glycerol
-
 ?
additional information enzyme activity with 1-, 2-, and 3- monoacylglycerols as substrates is similar Mus musculus ?
-
 ?
additional information enzyme activity with 1-, 2-, and 3-monoacylglycerols as substrates is similar Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MAG lipase
-
 Mus musculus
monoacylglycerol lipase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.8
-
 assay at Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000076
-
 i.e. IDFP, n-C12H25P(O)(OCH3)F, IC50 is 0.76 nM Mus musculus isopropyl dodecylfluorophosphate
0.0000008
-
 IC50 is 0.80 nM Mus musculus decyl benzodioxaphosphorin oxide
0.00000083
-
 IC50 is 0.83 nM Mus musculus dodecyl benzodioxaphosphorin oxide
0.0000029
-
 IC50 is 2.9 nM Mus musculus S-heptyl benzodioxaphosphorin oxide
0.000003
-
 i.e. EOFP, n-C8H17P(O)(OC2H5)F, IC50 is 3.0 nM Mus musculus ethyl octylphosphonofluoridate
0.000003
-
 i.e. MOFP, n-C8H17P(O)(OCH3)F, IC50 is 3.0 nM Mus musculus methyl octylphosphonofluoridate
0.0000031
-
 IC50 is 3.1 nM Mus musculus S-pentyl benzodioxaphosphorin oxide
0.000034
-
 IC50 is 34 nM Mus musculus chlorpyrifos oxon
0.000045
-
 IC50 is 45 nM Mus musculus heptyl benzodioxaphosphorin oxide
0.000051
-
 IC50 is 51 nM Mus musculus stearyl benzodioxaphosphorin oxide
0.00014
-
 IC50 is 140 nM Mus musculus octyl sulfonyl fluoride
0.00015
-
 IC50 is 150 nM Mus musculus O-n-octyl benzodioxaphosphorin oxide
0.00015
-
 IC50 is 150 nM Mus musculus N-n-heptyl benzodioxaphosphorin oxide
0.0002
-
 IC50 is 200 nM Mus musculus dodecyl sulfonyl fluoride
0.0023
-
 IC50 is 0.0023 mM Mus musculus paraoxon
0.012
-
 IC50 is 0.012 mM Mus musculus benzol
0.013
-
 IC50 is 0.013 mM Mus musculus dichlorvos
0.014
-
 IC50 is 0.014 mM Mus musculus diazoxon
0.045
-
 i.e. DFP, n-C8H17P(O)(OCH3)F, IC50 is 0.045 mM Mus musculus diisopropyl fluorophosphate
0.31
-
 IC50 is 0.31 nM Mus musculus S-nonyl benzodioxaphosphorin oxide