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Literature summary for 2.8.3.5 extracted from

  • Hasan, N.M.; Longacre, M.J.; Seed Ahmed, M.; Kendrick, M.A.; Gu, H.; Ostenson, C.G.; Fukao, T.; MacDonald, M.J.
    Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells (2010), Arch. Biochem. Biophys., 499, 62-68.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in INS-1832/13 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + acetoacetate Rattus norvegicus
-
 succinate + acetoacetyl-CoA
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus B2GV06
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic islet
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + acetoacetate
-
 Rattus norvegicus succinate + acetoacetyl-CoA
-
 r

Synonyms

Synonyms Comment Organism
SCOT
-
 Rattus norvegicus
succinyl-CoA:3-ketoacid-CoA transferase
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction insulinoma cell lines with more than 70% knockdown of enzyme activity shows more than 70% reduction in glucose- or methyl succinate-plus-beta-hydroxybutyrate-stimulated insulin release Rattus norvegicus