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Literature summary for 2.8.3.5 extracted from

  • MacDonald, M.J.; Longacre, M.J.; Langberg, E.C.; Tibell, A.; Kendrick, M.A.; Fukao, T.; Ostenson, C.G.
    Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes (2009), Diabetologia, 52, 1087-1091.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.3.5

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic islet of healthy individuals and of type 2 diabetes patients: decreased activity by 92% in the diabetic compared with the non-diabetic islets Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00003
-
 diabetic pancreatic islets Homo sapiens
0.0038
-
 nondiabetic pancreatic islets Homo sapiens

Synonyms

Synonyms Comment Organism
SCOT
-
 Homo sapiens
succinyl-CoA:3-ketoacid-CoA transferase
-
 Homo sapiens

General Information

General Information Comment Organism
additional information low enzyme expression is correlated with diabetis type 2 Homo sapiens
physiological function role of SCOT in insulin secretion Homo sapiens