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Literature summary for 2.8.3.5 extracted from

  • Fenselau, A.; Wallis, K.
    Substrate specificity and mechanism of action of acetoacetate coenzyme A transferase from rat heart (1974), Biochemistry, 13, 3884-3889.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,2-Difluorosuccinate strong Rattus norvegicus
3-Sulfopropanoate
-
Rattus norvegicus
acetoacetate
-
Rattus norvegicus
acetylene dicarboxylate weak Rattus norvegicus
Maleamate reversible, competitive Rattus norvegicus
Maleimide succinate or acetoacetate protects Rattus norvegicus
malonate kinetics Rattus norvegicus
Monomethylsuccinate competitive Rattus norvegicus
additional information no inhibition by glutarate, adipate, cis- or trans-cyclobutane-1,2-dicarboxylate, cis- or trans-cyclohexane-1,2-dicarboxylate, methylsuccinate, mercaptosuccinate, malate, aspartate, succinimide or iodoacetamide Rattus norvegicus
N-ethylmaleamate reversible, competitive Rattus norvegicus
N-ethylmaleimide succinate or acetoacetate protects Rattus norvegicus
oxalate kinetics Rattus norvegicus
Perfluorosuccinate strong Rattus norvegicus
succinamate competitive Rattus norvegicus
succinate product inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
acetoacetyl-CoA pH 8.1, 25°C Rattus norvegicus
0.28
-
succinyl-CoA pH 8.1, 25°C Rattus norvegicus
0.44
-
acetoacetate pH 8.1, 25°C Rattus norvegicus
28
-
succinate cosusbstrate: acetoacetyl-CoA, pH 8.1, 25°C Rattus norvegicus
35
-
Maleate cosusbstrate: acetoacetyl-CoA, pH 8.1, 25°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male adult Buffalo
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.88
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
frozen, partially purified preparation in phosphate solution, less than 10% loss of activity within 1-2 weeks Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no substrates are diacids with connecting chain lengths of 3 or more methylene groups Rattus norvegicus ?
-
?
succinyl-CoA + acetoacetate
-
Rattus norvegicus succinate + acetoacetyl-CoA
-
r
succinyl-CoA + maleate
-
Rattus norvegicus succinate + maleyl-CoA
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.72
-
succinate pH 8.1, 25°C Rattus norvegicus
3.7
-
acetoacetate pH 8.1, 25°C Rattus norvegicus
6.4
-
2,2-Difluorosuccinate pH 8.1, 25°C Rattus norvegicus
15
-
oxalate pH 8.1, 25°C Rattus norvegicus
18
-
Perfluorosuccinate pH 8.1, 25°C Rattus norvegicus
21
-
malonate pH 8.1, 25°C Rattus norvegicus