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Literature summary for 2.8.2.9 extracted from

  • Chung, K.H.; Ringer, D.P.; Shin, K.O.
    Influence of dietary zinc, copper and cadmium levels on rat liver aryl sulfotransferase IV activity (2006), Nutr. Sci., 9, 20-28.
No PubMed abstract available
Search for more literature for 2.8.2.9

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ strong inhibition in vitro and in vivo, 50% inhibition of purified enzyme at about 0.0025 mM, 50% inhibition in liver cytosol at about 0.025 mM Rattus norvegicus
Cu2+ elevated copper levels in the diet result in reduced enzyme levels in rat liver, strong inhibition in vitro and in vivo, 50% inhibition of purified enzyme at about 0.0025 mM, 50% inhibition in liver cytosol at about 0.025 mM Rattus norvegicus
Zn2+ indirect inhibition mechanism, strong inhibition in vitro and in vivo, 50% inhibition of purified enzyme at about 0.0025 mM, 50% inhibition in liver cytosol at about 0.025 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is involved in detoxification and is susceptible to downregulation by hepatotoxic xenobiotics, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in detoxification and is susceptible to downregulation by hepatotoxic xenobiotics, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
aryl sulfotransferase IV
-
 Rattus norvegicus
AST IV
-
 Rattus norvegicus