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Literature summary for 2.8.2.5 extracted from

  • Duelli, A.; Roennberg, E.; Waern, I.; Ringvall, M.; Kolset, S.O.; Pejler, G.
    Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases (2009), J. Immunol., 183, 7073-7083.
    View publication on PubMed
Search for more literature for 2.8.2.5

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin Mus musculus
-
 adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?
3'-phosphoadenylyl sulfate + chondroitin Mus musculus C57BL/6
-
 adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow cell C4ST-2 expression occurs in the early stage bone marrow cell cultures, the process of mast cell maturation does not alter the expression, low expression at day 0, followed by an increase in expression at later stages of culture Mus musculus
-
mast cell developed from bone marrow cells isolated from femur and tibia from C57BL/6 mice, mast cell maturation strongly correlates with the expression of C4ST-1 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + chondroitin
-
 Mus musculus adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?
3'-phosphoadenylyl sulfate + chondroitin
-
 Mus musculus C57BL/6 adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?
additional information chondroitin 4-sulfotransferase-1 and -2, which catalyze the 4-O-sulfation of nonsulfated GalNAc residues Mus musculus ?
-
 ?
additional information chondroitin 4-sulfotransferase-1 and -2, which catalyze the 4-O-sulfation of nonsulfated GalNAc residues Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
C4ST-1
-
 Mus musculus
C4ST-2
-
 Mus musculus
chondroitin 4-sulfotransferase 1
-
 Mus musculus
chondroitin 4-sulfotransferase 2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus A23187 causes a down-regulated expression of the C4ST-2 gene with 50% reduction after 1 h, followed by return to basal levels after 4.5 h down