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Literature summary for 2.8.2.4 extracted from

  • Kester, M.H.; Bulduk, S.; van Toor, H.; Tibboel, D.; Meinl, W.; Glatt, H.; Falany, C.N.; Coughtrie, M.W.; Schuur, A.G.; Brouwer, A.; Visser, T.J.
    Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters (2002), J. Clin. Endocrinol. Metab., 87, 1142-1150.
    View publication on PubMed
Search for more literature for 2.8.2.4

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin
-
 Homo sapiens
2-hydroxy-7,8-dichlorodibenzo-p-dioxin
-
 Homo sapiens
2-hydroxy-7,8-dichlorodibenzofuran
-
 Homo sapiens
3,3',5,5'-tetrachlorobisphenol A
-
 Homo sapiens
3-hydroxy-2,4,7,8,9-pentachlorodibenzofuran
-
 Homo sapiens
3-hydroxy-2,4,7,8-tetrachlorodibenzofuran
-
 Homo sapiens
4,4'-isopropyl idenediphenol-3,3',5,5'-tetrachlorobisphenol
-
 Homo sapiens
4,4'-isopropylidenediphenol
-
 Homo sapiens
4-hydroxy-2,3,4,5,6-pentabromodiphenylether
-
 Homo sapiens
additional information native liver enzyme is less potently inhibited than recombinant SULT1E1 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000004
-
 estradiol pH 7.2, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + estradiol Homo sapiens
-
 adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 r
3'-phosphoadenylylsulfate + estrone Homo sapiens
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzo-p-dioxine sulfate
-
 r
3'-phosphoadenylylsulfate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuran
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2-OH-1,3,7,8-tetrachlorinated dibenzofuranyl sulfate
-
 r
3'-phosphoadenylylsulfate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2-OH-3,7,8-trichlorinated dibenzo-p-dioxine sulfate
-
 r
3'-phosphoadenylylsulfate + 2-OH-4,2',4'-trichlorodiphenyl ether
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2-OH-4,2',4'-trichlorodiphenyl ethyl sulfate
-
 r
3'-phosphoadenylylsulfate + 2-OH-4,5,3',2',3',4'-tetrachlorated biphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
-
 r
3'-phosphoadenylylsulfate + 2-OH-6,7,8-trichlorinated dibenzofuran
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2-OH-6,7,8-trichlorinated dibenzofuranyl sulfate
-
 r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzo-p-dioxine sulfate
-
 r
3'-phosphoadenylylsulfate + 2-OH-7,8-dichlorinated dibenzofuran
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2-OH-7,8-dichlorinated dibenzofuranyl sulfate
-
 r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrabromo-4,4'-isopropylidendiphenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 3,5,3',5'-tetrabromo-4,4'-isopropylidendiphenyl sulfate
-
 r
3'-phosphoadenylylsulfate + 3,5,3',5'-tetrachloro-4,4'-isopropylidendiphenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 3,5,3',5'- tetrachloro-4,4'-isopropylidendiphenyl sulfate
-
 r
3'-phosphoadenylylsulfate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuran
-
 Homo sapiens adenosine 3',5'-bisphosphate + 3-OH-2,4,7,8-tetrachlorinated dibenzofuranyl sulfate
-
 r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuran
-
 Homo sapiens adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8,9-pentachlorinated dibenzofuranyl sulfate
-
 r
3'-phosphoadenylylsulfate + 3-OH-2,6,7,8-tetrachlorinated dibenzofuran
-
 Homo sapiens adenosine 3',5'-bisphosphate + 3-OH-2,6,7,8-tetrachlorinated dibenzofuranyl sulfate
-
 r
3'-phosphoadenylylsulfate + 3-OH-4,5,3',4'-tetrachlorated biphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 3-OH-4,5,3',4'-tetrachlorated biphenyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4,4'-(OH)2-3,5,3',5'-tetrachlorated biphenyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-hydroxy-3,2',3',4',5'-pentachlorobiphenyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuran
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-OH-1,3,6,7-tetrachlorinated dibenzofuranyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-OH-2',4',6'-tribromodiphenyl ether
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-OH-2',4',6'-tribromodiphenyl ethyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-OH-3',2',4',6'-tetrabromodiphenyl ether
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-OH-3',2',4',6'-tetrabromodiphenyl ethyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-OH-3',5,2',4',6'-pentabromodiphenyl ether
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-OH-3',5,2',4',6'- pentabromodiphenyl ethyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-OH-3,3',4'-trichlorated biphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-OH-3,3',4'-trichlorated biphenyl sulfate
-
 r
3'-phosphoadenylylsulfate + estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 r
3'-phosphoadenylylsulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r
additional information 1-hydroxy-2,4,7,8-tetrachlorodibenzofuran is no substrate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SULT1E1
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000002
-
 2-hydroxy-7,8-dichlorodibenzo-p-dioxin pH 7.2, 37°C Homo sapiens
0.00000615
-
 3-hydroxy-2,4,7,8,9-pentachlorodibenzofuran pH 7.2, 37°C Homo sapiens
0.000035
-
 3,3',5,5'-tetrachlorobisphenol A pH 7.2, 37°C Homo sapiens
0.00006
-
 2-hydroxy-1,3,7,8-tetrachlorodibenzo-p-dioxin pH 7.2, 37°C Homo sapiens
0.00015
-
 4-hydroxy-2,3,4,5,6-pentabromodiphenylether pH 7.2, 37°C Homo sapiens
0.00027
-
 2-hydroxy-7,8-dichlorodibenzofuran pH 7.2, 37°C Homo sapiens
0.014
-
 4,4'-isopropylidenediphenol pH 7.2, 37°C Homo sapiens