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Literature summary for 2.8.2.22 extracted from

  • Konishi-Imamura, L.; Kim, D.H.; Koizumi, M.; Kobashi, K.
    Regulation of arylsulfate sulfotransferase from a human intestinal bacterium by nucleotides and magnesium ion (1995), J. Enzyme Inhib., 8, 233-241.
    View publication on PubMed
Search for more literature for 2.8.2.22

Inhibitors

Inhibitors Comment Organism Structure
ATP non-competitive, enzyme is not phosphorylated but binds ATP Eubacterium sp.
Cu2+ 50% inhibition at 0.6 mM Eubacterium sp.
diphosphate non-competitive Eubacterium sp.
nucleotide triphosphates non-competitive Eubacterium sp.
Pentachlorophenol 50% inhibition at 0.0255 mM with tyramine as substrate Eubacterium sp.
Zn2+ 99% inhibition at 0.6 mM Eubacterium sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 51% increase at 0.6 mM Eubacterium sp.
Mn2+ 23% increase at 0.6 mM Eubacterium sp.

Organism

Organism UniProt Comment Textmining
Eubacterium sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl sulfate + phenol
-
 Eubacterium sp. phenyl sulfate + 4-nitrophenol
-
 ?
4-nitrophenyl sulfate + tyramine
-
 Eubacterium sp. 4-(2-aminoethyl)phenyl sulfate + 4-nitrophenol
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.2
-
 diphosphate for tyramine Eubacterium sp.
0.45
-
 ATP for tyramine Eubacterium sp.
0.66
-
 ATP for 4-nitrophenyl sulfate Eubacterium sp.
0.7
-
 diphosphate for 4-nitrophenyl sulfate Eubacterium sp.