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Literature summary for 2.8.2.20 extracted from

  • Hosoda, Y.; Sasaki, N.; Agui, T.
    Female infertility in grt mice is caused by thyroid hormone deficiency, not by insufficient TPST2 activity in the reproductive organs (2008), J. Vet. Med. Sci., 70, 1043-1049.
    View publication on PubMed
Search for more literature for 2.8.2.20

Cloned(Commentary)

Cloned (Comment) Organism
isozyme TPST-2, expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of isozyme TPST-2 deficient growth-retarded mutant mice, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Mus musculus 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + protein tyrosine Mus musculus
-
 adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 wild-type DW/J mice and mutant grt mice
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
liver high TPST-2 expression level Mus musculus
-
lung low TPST-2 expression level Mus musculus
-
additional information the expression of TPST2 protein in various tissues of wild-type DW/J mice Mus musculus
-
ovary
-
 Mus musculus
-
testis
-
 Mus musculus
-
thyroid gland
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + protein tyrosine
-
 Mus musculus adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
TPST2
-
 Mus musculus
tyrosylprotein sulfotransferase-2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction deficiency in the enzymatic activity of isozyme TPST2 causes growth-retardation in mice, autosomal recessive hypothyroidism, and lifelong female infertility. The isozyme deficiency is also involved in severe thyroid hypogenesis and consequent dwarfism, due to the impairment of the tyrosine sulfation of thyroid-stimulating hormone receptor by mutant TPST2 Mus musculus