Cloned (Comment) | Organism |
---|---|
isozymes TPST-1 and TPSt-2, geno- and phenotyping of wild-types and mutants | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | isozymes TPST-1 and TPSt-2, generation of single and double knockout mice. Double knockout mice completely lack the ability to sulfate peptidyltyrosine, Tpst2-/- mice show primary hypothyroidism, but that Tpst1-/- mice are euthyroid, phenotypes, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + protein tyrosine | Mus musculus | - |
adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozymes TPST-1 and TPST-2 | - |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + protein tyrosine | - |
Mus musculus | adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | tyrosine sulfation is required for normal pulmonary function at birth, and isozyme TPST-2 is required for normal thyroid gland function | Mus musculus |